THERAtRAME discovers and develops first-in-class small molecules targeting the tRNA epitranscriptomics for the benefit of cancer patients.


Our values, our Mission

At THERAtRAME, our mission is to expand treatment possibilities for cancer patients who currently have none. We are guided by scientific rigor, curiosity, and a deep commitment to patients. By exploring new biological frontiers, we aim to transform fundamental discoveries into meaningful therapies, working with integrity, collaboration, and a long-term vision for impact.

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Our work: an innovative platform

At the core of our work is a simple idea: cancer cells survive by adapting. Our proprietary platform targets tRNA modifications, a key layer of gene regulation that drives this adaptability and resistance. By disrupting this process, we aim to develop a new class of therapies for immune-refractory and target-therapy resistant tumors.

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Our investment plan

Our investment plan is focused on advancing our lead program into clinical development while strengthening our platform and biomarker capabilities. By combining disciplined capital allocation with clear milestones, we aim to efficiently generate clinical proof-of-concept and unlock long-term value across multiple indications.

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Latest news

Our goal is to transform pioneering research into real-world solutions for patients with cancers that currently have no effective treatments. By combining breakthrough science with strategic partnerships, we aim to position THERAtRAME as a leader in next-generation oncology therapeutic.

Francesca RAPINO - Co-Founder